Using the AVMATRIX VS0601 is easy. First, connect your devices to the appropriate inputs - use the 4 SDI and 2 HDMI ports. Then, select the input you want to display using the available transition options like T - Bar, AUTO, or CUT. You can also play around with effects such as MIX, FADE, or WIPE. For the PiP mode, you can adjust its size and position to your liking. When it comes to audio, you can choose from 3.5mm stereo, RCA audio, or SDI/ HDMI embedded audio. As for the GPIO interface, it helps with the live tally system, so make sure it's properly connected if you're using that feature. In case of an emergency, the FTB will come in handy. For maintenance, keep the device in a cool, dry place. Regularly check the connections to ensure they're secure. If you notice any issues, power off the device and check for loose cables or other visible problems.